A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone
In central nervous system (CNS) synapses, action potential-evoked neurotransmitter release is...
Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice
The cerebellar system helps modulate and fine-tune motor action. Purkinje cells (PCs) provide the...
Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type...
A calcium- and light-gated switch to induce gene expression in activated neurons
Despite recent advances in optogenetics, it remains challenging to manipulate gene expression in...
Regulation of Rho GTPase proteins during spine structural plasticity for the control of local dendritic plasticity.
While it is generally appreciated that learning involves the structural rearrangement of neuronal...
Hippocampal maturity promotes memory distinctiveness in childhood and adolescence
Adaptive learning systems need to meet two complementary and partially conflicting goals: detecting...
Dissociable effects of age and testosterone on adolescent impatience
The onset of adolescence is associated with an increase in transgressive behaviours—from juvenile...
A Methyl-Balanced Diet Prevents CRF-Induced Prenatal Stress-Triggered Predisposition to Binge Eating-like Phenotype
Binge eating (BE) is a common aberrant form of eating behavior, characterized by overconsumption of...
CaMKII Autophosphorylation Is Necessary for Optimal Integration of Ca2+ Signals during LTP Induction, but Not Maintenance
CaMKII plays a critical role in decoding calcium (Ca2+) signals to initiate long-lasting synaptic...
Does One Year of Schooling Improve Children’s Cognitive Control and Alter Associated Brain Activation?
The “5-to-7-year shift” refers to the remarkable improvements observed in children’s...