Brain Disorders and InjuryCognitionDevelopmentIntegrative Physiology and BehaviorJournal

Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

Artwork by Ryuji Yamashita © gallerysway.com

The hypothalamic–pituitary–adrenal axis is a pivotal component of an organism’s response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic–pituitary–adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.


Ramot, A., Jiang, Z., Tian, J., Nahum, T., Kuperman, Y., Justice, N. & Chen, A.
Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress.
Nature Neuroscience 20, 385–388 (2017)
DOI: http://dx.doi.org/10.1038/nn.4491